Background: Continuous diffusion of oxygen (CDO) to wounds has demonstrated better effectiveness in healing wounds than negative-pressure wound therapy (NPWT). However, there is limited evidence regarding the cost-effectiveness of CDO therapy and its comparison with NPWT.

Objectives: The purpose of this analysis is to report on the cost-effectiveness of CDO and NPWT using published clinical results as well as real-world clinical outcomes and cost information. The objectives included analyzing the cost-effectiveness of CDO therapy across multiple wound types and anatomical locations, testing the data for robustness, and comparing the cost-effectiveness using results from controlled clinical studies for CDO and NPWT